Growth Regulation

ABCG1 maintains high-grade glioma survival in vitro and in vivo
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH. ABCG1 maintains high-grade glioma survival in vitro and in vivo. Oncotarget. 2016 Mar 10. doi: 10.18632/oncotarget.8030. [Epub ahead of print]

Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival
Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516. PubMed PMID: 28380429; PubMed Central PMCID: PMC5464843.

Global microRNA profiling identified miR-10b-5p as a regulator of neurofibromatosis 1 (NF1)-glioma migration
Nix JS, Yuan M, Imada EL, Ames H, Marchionni L, Gutmann DH, Rodriguez FJ. Global microRNA profiling identified miR-10b-5p as a regulator of neurofibromatosis 1 (NF1)-glioma migration. Neuropathol Appl Neurobiol. 2021 Feb;47(1):96-107. doi: 10.1111/nan.12641. Epub 2020 Jul 22. PMID: 32603552.

Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma
Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J. Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma. PLoS One. 2018 May 22;13(5):e0190001. doi: 10.1371/journal.pone.0190001. eCollection 2018.

Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations
Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Cobb O, Dougherty JD, Gutmann DH. Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations. Stem Cell Reports. 2020 Apr 14;14(4):541-550. doi: 10.1016/j.stemcr.2020.03.007. Epub 2020 Apr 2. PMID: 32243842; PMCID: PMC7160375. *co-first authors

Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1
Freret ME, Anastasaki C, Gutmann DH. Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1. Neurol Genet. 2018 Jul 23;4(4):e261. doi: 10.1212/NXG.0000000000000261. eCollection 2018 Aug.

KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth
Anastasaki C, Dahiya S, Gutmann DH. KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth. Oncotarget. 2017 Jul 18;8(29):47574-47585. doi: 10.18632/oncotarget.17736. PubMed PMID: 28548933; PubMed Central PMCID: PMC5564588.

Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1
Anastasaki C, Mo J, Chen JK, Chatterjee J, Pan Y, Scheaffer SM, Cobb O, Monje M, Le LQ, Gutmann DH. Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1. Nat Commun. 2022 May 19;13(1):2785. doi: 10.1038/s41467-022-30466-6. PMID: 35589737; PMCID: PMC9120229.

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
Wegscheid ML, Anastasaki C, Hartigan KA, Cobb OM, Papke JB, Traber JN, Morris SM, Gutmann DH. Patient-derived iPSC-cerebral organoid modeling of the 17a11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Rep 2021; July 6 36:109315. doi: 10.1016/j.celrep.2021.109315 PMID:34233200.

RAS and beyond: the many faces of the neurofibromatosis type 1 protein
Anastasaki C, Orozco P, Gutmann DH. RAS and beyond: the many faces of the neurofibromatosis type 1 protein. Dis Model Mech. 2022 Feb 1;15(2):dmm049362. doi: 10.1242/dmm.049362. Epub 2022 Feb 21. PMID: 35188187; PMCID: PMC8891636.

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. Oncotarget. 2017 Apr 18;8(32):52474-52487. doi: 10.18632/oncotarget.17193. eCollection 2017 Aug 8. PubMed PMID: 28881745; PubMed Central PMCID: PMC5581044.