Stem Cells
Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterization
Anastasaki C, Wilson AF, Chen AS, Wegscheid ML, Gutmann DH. Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterization. STAR Protoc. 2022 Feb 8;3(1):101173. doi: 10.1016/j.xpro.2022.101173. PMID: 35199037; PMCID: PMC8844852.
Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations
Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Cobb O, Dougherty JD, Gutmann DH. Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations. Stem Cell Reports. 2020 Apr 14;14(4):541-550. doi: 10.1016/j.stemcr.2020.03.007. Epub 2020 Apr 2. PMID: 32243842; PMCID: PMC7160375. *co-first authors
Human stem cell modeling in neurofibromatosis type 1 (NF1)
Wegscheid ML, Anastasaki C, Gutmann DH. Human stem cell modeling in neurofibromatosis type 1 (NF1). Exp Neurol. 2017 Apr 6. pii: S0014-4886(17)30094-8. doi: 10.1016/j.expneurol.2017.04.001. [Epub ahead of print] Review. PubMed PMID: 28392281; PubMed Central PMCID: PMC5630478.
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins
Mo J, Anastasaki C, Chen Z, Shipman T, Papke J, Yin K, Gutmann DH, Le LQ. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. J Clin Invest. 2021 Jan 4;131(1):e139807. doi: 10.1172/JCI139807. PMID: 33108355; PMCID: PMC7773354.
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
Wegscheid ML, Anastasaki C, Hartigan KA, Cobb OM, Papke JB, Traber JN, Morris SM, Gutmann DH. Patient-derived iPSC-cerebral organoid modeling of the 17a11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Rep 2021; July 6 36:109315. doi: 10.1016/j.celrep.2021.109315 PMID:34233200.