Tumor Microenvironment & Immunology
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
Chatterjee J, Sanapala S, Cobb O, Bewley A, Goldstein AK, Cordell E, Ge X, Garbow JR, Holtzman MJ, Gutmann DH. Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia. Nat Commun. 2021 Dec 8;12(1):7122. doi: 10.1038/s41467-021-27455-6. PMID: 34880260.
Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth
Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH. Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth. Genes Dev. 2018 Apr 1;32(7-8):491-496. doi: 10.1101/gad.310797.117. Epub 2018 Apr 9.
Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival
Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516. PubMed PMID: 28380429; PubMed Central PMCID: PMC5464843.
Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology
Toonen JA, Solga AC, Ma Y, Gutmann DH. Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology. J Exp Med. 2017 Jan;214(1):17-25. doi: 10.1084/jem.20160447. Epub 2016 Dec 6. PubMed PMID: 27923908; PubMed Central PMCID: PMC5206494.
Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia
Guo X, Pan Y, Gutmann DH. Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia. Neuro Oncol. 2019 Oct 9;21(10):1250-1262. doi: 10.1093/neuonc/noz080. PMID: 31111915; PMCID: PMC6784288.
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins
Mo J, Anastasaki C, Chen Z, Shipman T, Papke J, Yin K, Gutmann DH, Le LQ. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. J Clin Invest. 2021 Jan 4;131(1):e139807. doi: 10.1172/JCI139807. PMID: 33108355; PMCID: PMC7773354.
Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation
de Andrade Costa A, Chatterjee J, Cobb O, Cordell E, Chao A, Schaeffer S, Goldstein A, Dahiya S, Gutmann DH. Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation. Neurooncol Adv. 2021 Dec 31;4(1):vdab194. doi: 10.1093/noajnl/vdab194. PMID: 35187488; PMCID: PMC8852255.
KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production
Chen R, Keoni C, Waker CA, Lober RM, Chen YH, Gutmann DH. KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production. Neoplasia. 2019 Jan;21(1):52-60. doi: 10.1016/j.neo.2018.11.007. Epub 2018 Nov 30. Erratum in: Neoplasia. 2020 Mar;22(3):e1. PMID: 30504064; PMCID: PMC6277251.
Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology
Gutmann DH, Kettenmann H. Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology. Neuron. 2019 Nov 6;104(3):442-449. doi: 10.1016/j.neuron.2019.08.028. PMID: 31697921; PMCID: PMC7288606.
Midkine activation of CD8 + T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth
Guo X, Pan Y, Xiong M, Sanapala S, Anastasaki C, Cobb O, Dahiya S, Gutmann DH. Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. Nat Commun. 2020 May 1;11(1):2177. doi: 10.1038/s41467-020-15770-3. PMID: 32358581; PMCID: PMC7195398.
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. 2021 Jun;594(7862):277-282. doi: 10.1038/s41586-021-03580-6. Epub 2021 May 26. PMID: 34040258; PMCID: PMC8346229.
RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth
De Andrade Costa A, Chatterjee J, Cobb O, Sanapala S, Guo X, Dahiya S, Gutmann DH. RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. Neuro Oncol. 2021 May 27:noab130. doi: 10.1093/neuonc/noab130. Online ahead of print. PMID: 34043012.
T lymphocytes as dynamic regulators of glioma pathobiology
Cordell EC, Alghamri MS, Castro MG, Gutmann DH. T lymphocytes as dynamic regulators of glioma pathobiology. Neuro Oncol. 2022 Mar 23:noac055. doi: 10.1093/neuonc/noac055. Epub ahead of print. PMID: 35325210.
Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1
Haage V, Elmadany N, Roll L, Faissner A, Gutmann DH, Semtner M, Kettenmann H. Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1. Brain Behav Immun. 2019 Oct; 81:470-483. doi: 10.1016/j.bbi.2019.06.047. Epub 2019 Jul 2. PMID: 31271872
The Sociobiology of Brain Tumors
Gutmann DH. The Sociobiology of Brain Tumors. Adv Exp Med Biol. 2020;1225:115-125. doi: 10.1007/978-3-030-35727-6_8. PMID: 32030651.
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. Oncotarget. 2017 Apr 18;8(32):52474-52487. doi: 10.18632/oncotarget.17193. eCollection 2017 Aug 8. PubMed PMID: 28881745; PubMed Central PMCID: PMC5581044.