Based on stunning experimental findings initially reported by Michelle Monje-Deisseroth, MD, PhD (Stanford University) for high-grade glioma, we have initiated studies with her laboratory to define the contribution of neuronal activity to low-grade optic glioma growth. These investigations may yield important new insights into the pathogenesis of pediatric tumors arising in the developing brain, as well as reveal new approaches for treating brain tumors (chronotherapy).
Current projects in the Gutmann research laboratory are focused on determining the cellular and molecular mechanisms underlying neuronal control of nervous system tumor formation and growth.