Professors Kettenmann and Gutmann are co-directing a team of graduate student trainees whose projects aim to define the role of microglia in brain tumors and autism in NF1. These projects will leverage a combination of human induced pluripotent stem cells (iPSCs) and mice harboring mutations in the NF1 gene. In these studies, they hope to determine how the NF1 protein, neurofibromin, controls brain function in health, and understand the consequences of NF1 gene mutation in microglia on glioma formation and progression, nerve cells relevant to autism and behavior, and brain repair following stroke and nervous system injury.