Research Focus
For the past 30 years, the Gutmann laboratory has focused on discovering the genomic, genetic, cellular and molecular determinants that cause nervous system dysfunction by leveraging a combination of novel genetically engineered mice, human induced pluripotent stem cells, bioinformatic approaches, and multi-omic analysis methodologies.
We use the neurogenetic syndrome, neurofibromatosis type 1 (NF1), an autosomal dominant condition in which affected children and adults are at increased risk of developing brain and nerve tumors, attention deficit and autism, as well as many other neurologic problems. In this manner, NF1 becomes a model system to study the intersection between normal brain development and tumorigenesis.
Our Mission
Our mission is to identify the factors that underlie nervous system disease heterogeneity relevant to the implementation of precision, or personalized, medicine strategies, as well as to discover new treatments for individuals with NF1. Lessons learned from NF1 have already changed the way we think about and treat other related medical conditions in the general population.
Areas of Interest
Cancer
Neuroscience
Cancer
Immunology
Modeling Human
Neurologic Disease
Meet our Principal Investigator
David H. Gutmann, MD, PhD is the Principal Investigator, Physician in Pediatric Neurology & Director of Neurofibromatosis (NF) Center.
Meet our
Team Members
Our team is comprised of researchers at all levels of training who bring their individual talents and expertise to the scientific mission of our laboratory.
Training
Opportunities
We welcome dedicated trainees at all levels to participate in research and development opportunities through our laboratory and its affiliated programs.
Neurofibromatosis Center
The Washington University Neurofibromatosis Center is a collaboration between clinicians and laboratory scientists focused on accelerating the pace of scientific discovery and its application to the care of individuals with NF.
Connect with Us
Gutmann Lab (@gutmannlab.bsky.social)