People

Principal Investigator

PI

David H. Gutmann, MD, PhD, is the Donald O. Schnuck Family Professor, Vice Chair for Research Affairs in Neurology and Director of the Washington University NF Center

David H. Gutmann, MD, PhD

Dr. Gutmann received his MD and PhD degrees at the University of Michigan Medical School, working as a graduate student in immunogenetics under the guidance of Dr. John Niederhuber. He then received residency training in Neurology at the University of Pennsylvania, where he was mentored by Dr. Kenneth Fischbeck in neurogenetics, prior to joining the laboratory of Dr. Francis S. Collins to identify the function of the NF1 gene.

For over 25 years, Dr. Gutmann has cared for children and adults with neurofibromatosis, as well as directed a basic research laboratory focused on using NF as a genetic model system to better understand normal brain and brain tumor development relevant to improving the lives of people with NF and related disorders. His work has been internationally recognized, with numerous honors, including the 2012 Children’s Tumor Foundation Frederich von Recklinghausen and an R35 Research Program Award from the National Institutes of Health.

In addition, Dr. Gutmann was awarded a Alexander von Humboldt Award and Berlin Institute of Health Einstein Fellowship to establish an international research team focused on NF1 and microglia in Professor Helmut Kettenmann’s laboratory at the Max Delbruck Center in Berlin.

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Faculty

Corina Anastasaki, PhD
Instructor in Neurology

Education:
BS, Genetics, University of York, 2006
PhD in Human Genetics, University of Edinburgh, 2011
Research Focus:
Discovering new approaches (utilizing iPSCs) to identify targets for managing NF1 neuronal dysfunction.

View Dr. Anastasaki’s publications

Staff Scientists

Jason Papke, MS

Education:
MS, St. Louis University
Research Focus:
Stem cell modeling of human neurologic diseases.

 

Suzanne Scheaffer, MS

Education:
MS, St. Louis University
Research Focus:
To discover therapies that prevent or improve vision in Nf1 optic glioma mice.

 

Bioinformatics Specialist

Olivia Cobb, MS

Education:
BA, Liberal Arts, Thomas Aquinas College, 2016
MS, Biostatistics, Washington University in St. Louis, 2019
Research Focus:
Bioinformatic analytics for laboratory projects.

 

Technicians

Ji-Kang Chen, MS

Education:
BS, Chang Gung University, China, 2016
MS, State University of New York at Oswego, 2018
MS, National Yang-Ming University, 2019
Research Focus:
Neuronal regulation of pediatric brain tumor formation and growth.

Kelly Hartigan, BS

Education:  
BS, Washington University in St. Louis, 2019
Research Focus:
Mouse and hiPSC modeling of NF1 brain development and glioma.

 

Postdoctoral Fellows

Nicole Brossier, MD, PhD

Education:
MD, PhD, University of Alabama, Birmingham
Research Focus:
Defining the cells of origin for pediatric
low-grade brain tumors (gliomas).

Alexander Chen, PhD

Education:
BA, Lehigh University, Bethlehem, PA
PhD in Cancer Biology, Emory University, Atlanta, GA
Research Focus:
Exploring the role of cell of origin in adult and pediatric brain tumors.

Amanda Costa, PhD

Education:
MS, University of Porto, Portugal
PhD, Max Delbrück Center, Berlin
Research Focus:
Integrative approaches to brain tumor therapy.

Jit Chatterjee, PhD

Education:
BSc, Fergusson College, Pune, India
MSc, MS University Baroda, Gujarat, India
PhD in Neurobiology, Department of Applied Zoology, Mangalore University, Mangalore, India
Research Focus:
The role of T cells in experimental glioma models.

Yunshuo “Caroline” Tang, MD, PhD

Education:
BA, University of California, Berkeley, 2005
PhD, University of California, San Francisco, 2015
MD, University of California, San Francisco, 2017
Research Focus:
My research focuses on defining why retinal ganglion cells die in the setting of Nf1 optic glioma, and result in vision loss.  I am using a variety of approaches, including single cell RNA sequencing, to determine which RGC subtypes are most susceptible to optic glioma-induced death, and to leverage these findings to identify new treatments to reduce vision loss.

Graduate Trainees

Alice Bewley, BA, BS

Education:
BA, BS, Lyon College, 2019
MS, Biostatistics, Washington University in St. Louis, Expected Graduation Dec 2020
Research Focus:
NF1 mutational effects

Elizabeth Cordell, BA

Education:
BA, University of Chicago, 2019
Research Focus:
Immunobiology of pediatric brain tumors

Andrea Goldstein, BS

Education:
BS, Stanford University, 2014
MD, University of Missouri School of Medicine, 2021
Research Focus:
Immune cell interactions in the low-grade glioma tumor microenvironment

Undergraduate Trainees

Astoria Chao

Education:
Pursuing undergraduate degree, Washington University in St. Louis
Research Focus:
Currently training with Jason Papke.

Kyra Rosen

Education:
Pursuing undergraduate degree at Washington University in St. Louis.
Research Focus:
Analysis of healthcare delivery and NF1.

Sharanya Thondapu

Education: 
Pursuing undergraduate degree, Washington University in St. Louis
Research Focus:
Working with Dr. Nicole Brossier to define the cell of origin for NF1 low-grade brain tumors using genetically engineered mice.

Anna Wilson

Education: 
Pursuing undergraduate degree, Washington University in St. Louis
Research Focus:
Working with Dr. Corina Anastasaki to study the function of neurons with NF1 mutations.

 

International NF1 Collaboration

Lab Alumni