Using NF1 as a genetic model system to understand growth and differentiation in the normal brain, the Gutmann laboratory aims to characterize the genomic, genetic, cellular, and molecular factors that contribute to the development of nervous system tumors (gliomas and neurofibromas), brain development and behavioral deficits.
Defining these contributing factors represents the first step toward establishing new treatments for children and adults with NF1. Moreover, NF1 provides unique opportunities to unravel the complexities of related medical problems in the general population, including adult and childhood brain tumors, nerve tumors, sarcoma and autism.
Areas of investigation
Learn more about our various areas of research, which include:
- Growth regulation in the nervous system
- Stem cells in brain development and cancer
- Tumor microenvironment and immunology
- Genetics and genomics of cancer
- Genetically-engineered mouse models of cancer
- Sexually-dimorphic effects in cancer
- Neuronal influences on cancer development and progression
- Precision medicine and oncology